Published on: Dec 25, 2025
Secretome is a fluid secreted by stem cells that contains proteins and growth factors. In theory, this bioactive substance has the potential to support tissue regeneration, accelerate wound healing, and contribute to the treatment of degenerative diseases. However, most applications of secretome remain in the research phase and are not yet supported by clear regulations regarding safety and efficacy.
At present, the rise of unregulated and illegal practices poses potential risks to public health. Consequently, further scientific research and the establishment of strict regulatory frameworks are essential to ensure the safe development and lawful clinical use of secretome in hospital settings.
Professor Y. Widodo Wirohadidjojo from the Department of Dermatology and Venereology, FK-KMK UGM, noted that stem cell technology represents an important advancement in regenerative therapy, particularly in addressing skin aging. According to him, stem cell derivatives are capable of slowing the biological mechanisms associated with aging skin.
“From an international perspective, secretome is now considered somewhat outdated, with greater attention shifting toward exosomes. This is why my discussion focuses more on the role of stem cells in skin aging,” he explained.
From an orthopedic standpoint, Lutfi Hidayat, an orthopedic specialist at UGM Academic Hospital (RSA UGM), described how orthopedics has traditionally focused on reconnecting bones. Recent advances in stem cell technology, however, enable clinicians to enhance the body’s biological response, leading to faster, stronger, and more natural healing.
“Healing naturally occurs in stages within the body. The challenge lies in accelerating this process without disrupting its natural mechanisms, so that functional recovery is improved. We hope to move from being ‘carpenters’ to becoming ‘farmers’—nurturing seeds (cells), providing fertilizers (secretome or exosomes), and supporting the healing environment,” he said.
Holly Ametati, a lecturer in dermatology and venereology at Diponegoro University, shared her clinical experience using secretome gel for wound treatment. She presented case outcomes involving pemphigus vulgaris, pyoderma gangrenosum, pressure ulcers, burn injuries, and allergic contact dermatitis. All five cases showed positive results in wound healing.
Meanwhile, Dr. Andreasta Meliala, Head of the UGM Integrated Health Services Bureau, emphasized the importance of expanding the use of stem cell–based therapies in hospital services so that individuals from diverse backgrounds can benefit. He stated that hospitals play a crucial role in facilitating the development and integration of stem cell technologies into clinical practice.
Source: https://ugm.ac.id/en/news/affordable-stem-cell-therapy-services-need-stronger-support-experts-say/
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